We are delighted to announce a new installment of MetOSite. The January 2023 release collects some very interesting contributions made during the past year 2022. Thus, He and coworkers presented strong evidence that the redox state of M239 controls the oligomerization state of pyruvate kinase M2 and the enzymatic activity of the protein. These authors also proved that the oxidation of M239 has direct implications on the metastatic capacity of pancreatic adenocarcinoma cells (Molecular Cell 82:3045-3060).
Another important contribution to the field of methionyl residues modification that appeared in 2022 came from the laboratory of Sina Ghaemmaghami at the University of Rochester. These authors identified, by mass spectrometry, over 280 novel sites for in vivo methionine oxidation in the brain of mice. They present very convincing evidence that under normal conditions, methionine sulfoxidation may be a biologically regulated process rather than a result of stochastic chemical damage (J. Proteome Res. 21:1495-1509).
Finally, work published in 2019 and describing the impact of methionine oxidation on the biological properties of diverse helicases (Sci. Adv. 5(8):eaax1031) has been reviewed and relevant data have now been incorporated to the current release of the MetOSite database.